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Depression: Not Just The Blues The blues are a natural, inescapable part of living. Feeling unhappy is a normal reaction to a loss or other bad experience in life. However, a blue period that won't let up or keeps coming back may be a sign of depression, an illness that involves changes in brain chemicals. Depression affects the way you feel, think, and act. Depression drains all the joy out of life and leaves you feeling helpless, worthless, and unable to cope. But, with help, you should be able to enjoy life again.
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