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primary amyloidosis a systemic form in which the deposited fibrillar material is AL amyloid; it may be due to either aberrant synthesis or processing of immunoglobulin light chains. It is associated with tumors or dyscrasias of immunoglobulin-producing plasma cells and affects some combination of the skin and subcutaneous tissue, nerves, liver, spleen, heart, kidney, intestine, and tongue. Treatment usually includes chemotherapy or stem cell transplantation. Called also AL amyloidosis.

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